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  lüll Tick-borne rickettsioses around the world: emerging diseases challenging old  concepts Parola P; Paddock CD; Raoult DClin Microbiol Rev  2005[Oct]; 18 (4): 719-56During most of the 20th century, the epidemiology of tick-borne rickettsioses  could be summarized as the occurrence of a single pathogenic rickettsia on each  continent. An element of this paradigm suggested that the many other  characterized and noncharacterized rickettsiae isolated from ticks were not  pathogenic to humans. In this context, it was considered that relatively few  tick-borne rickettsiae caused human disease. This concept was modified  extensively from 1984 through 2005 by the identification of at least 11  additional rickettsial species or subspecies that cause tick-borne rickettsioses  around the world. Of these agents, seven were initially isolated from ticks,  often years or decades before a definitive association with human disease was  established. We present here the tick-borne rickettsioses described through 2005  and focus on the epidemiological circumstances that have played a role in the  emergence of the newly recognized diseases.|Animals[MESH]|Arthropod Vectors/*microbiology[MESH]|Communicable Diseases, Emerging[MESH]|Disease Reservoirs[MESH]|Humans[MESH]|Rickettsia Infections/diagnosis/drug therapy/*epidemiology[MESH]|Rickettsia/classification/genetics/isolation & purification[MESH]|Tick-Borne Diseases/*diagnosis/epidemiology[MESH]|Ticks/*microbiology[MESH] |