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Central pontine myelinolysis: case series and review Musana AK; Yale SHWMJ 2005[Aug]; 104 (6): 56-60OBJECTIVE: To review central pontine myelinolysis (CPM) and osmotic demyelination syndrome (ODS) and describe the clinical features, etiologic factors, and clinical outcomes of 6 patients diagnosed with CPM or ODS. STUDY DESIGN: A retrospective case series. METHODS: Medical records of patients diagnosed with CPM or ODS at Marshfield Clinic/St. Joseph's Hospital from 1986 to 2003 were reviewed. Chart abstraction was completed with a standardized data abstraction form. RESULTS: Six patients were identified, ranging in age from 31-73 years (mean age = 51.5 years). Clinical presentations were nonspecific. Common symptoms included lethargy and dysarthria. Five of the 6 patients had chronic alcoholism. All had improvements in their clinical conditions upon hospital discharge. CONCLUSIONS: CPM and ODS are rare demyelinating diseases of the pons and extrapontine sites. Prompt diagnosis and management of associated complications are essential for favorable clinical outcomes.|Adult[MESH]|Aged[MESH]|Diagnosis, Differential[MESH]|Female[MESH]|Humans[MESH]|Male[MESH]|Middle Aged[MESH]|Myelinolysis, Central Pontine/*diagnosis/etiology/physiopathology/*therapy[MESH]|Prognosis[MESH]|Retrospective Studies[MESH] |
