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lüll Prediction and validation of microRNAs and their targets Bentwich IFEBS Lett 2005[Oct]; 579 (26): 5904-10MicroRNAs are short non-coding RNAs that inhibit translation of target genes by binding to their mRNAs, and have been shown to play a central role in gene regulation in health and disease. Sophisticated computer-based prediction approaches of microRNAs and of their targets, and effective biological validation techniques for validating these predictions, now play a central role in discovery of microRNAs and elucidating their functions.|Algorithms[MESH]|Animals[MESH]|Artificial Intelligence[MESH]|Binding Sites[MESH]|Computational Biology[MESH]|Conserved Sequence[MESH]|Evolution, Molecular[MESH]|Humans[MESH]|MicroRNAs/*chemistry/physiology[MESH]|Microarray Analysis/*methods[MESH]|Models, Biological[MESH]|Models, Genetic[MESH]|RNA Interference[MESH]|RNA Precursors[MESH]|RNA, Messenger/metabolism[MESH]|RNA, Plant[MESH]|RNA/chemistry[MESH] |