Warning: Undefined variable $zfal in C:\Inetpub\vhosts\kidney.de\httpdocs\mlpefetch.php on line 525
Deprecated: str_replace(): Passing null to parameter #3 ($subject) of type array|string is deprecated in C:\Inetpub\vhosts\kidney.de\httpdocs\mlpefetch.php on line 525
Warning: Undefined variable $sterm in C:\Inetpub\vhosts\kidney.de\httpdocs\mlpefetch.php on line 530
Warning: Undefined variable $sterm in C:\Inetpub\vhosts\kidney.de\httpdocs\mlpefetch.php on line 531
English Wikipedia
Nephropedia Template TP (
Twit Text
DeepDyve Pubget Overpricing |
lüll Immunotherapy with agonistic anti-CD137: two sides of a coin Sun Y; Chen JH; Fu YCell Mol Immunol 2004[Feb]; 1 (1): 31-6CD137 (4-1BB), a member of the TNF receptor superfamily, is an inducible T cell costimulatory receptor primarily expressed on activated CD4+ and CD8+ T cells. Agonistic monoclonal antibodies (mAbs) against CD137 greatly enhance T cell-mediated immune responses against many types of tumors and viruses. Surprisingly, these agonists also showed therapeutic effects in several autoimmune diseases. These findings suggest that in different disease environments, CD137 engagement with agonist mAb in vivo can diametrically modulate immune response outcomes. Therefore, CD137 agonists represent a promising immunotherapeutic approach to a wide array of disparate immune disorders. However, CD137's potency in modulating immune response necessitates caution when targeting CD137 clinically.|*Immune System Diseases/immunology/therapy[MESH]|*Immunotherapy[MESH]|Animals[MESH]|Antibodies, Monoclonal/*immunology[MESH]|Antigens, CD/*immunology[MESH]|Humans[MESH]|Receptors, Nerve Growth Factor/*immunology[MESH]|Receptors, Tumor Necrosis Factor/*immunology[MESH]|T-Lymphocytes/immunology[MESH]|Tumor Necrosis Factor Receptor Superfamily, Member 9[MESH] |