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lüll Small RNA asymmetry in RNAi: function in RISC assembly and gene regulation Hutvagner GFEBS Lett 2005[Oct]; 579 (26): 5850-7RNAi is a conserved gene-specific regulatory mechanism, which silences target gene expression transcriptionally and post-transcriptionally. The RNAi machinery converts the sequence specific information of a long double stranded RNAs (dsRNAs) into small 21-22 nt long dsRNAs (siRNAs, miRNAs) which assemble into an effector complex, the RNA induced silencing complex (RISC). RISC assembly is asymmetric; one strand of an siRNA or a miRNA preferentially incorporates into the RNA-protein complex. Here, I review the rules of the asymmetric RISC formation and discuss their possible regulatory function in several steps in RNAi.|*Gene Expression Regulation[MESH]|*RNA Interference[MESH]|Animals[MESH]|Base Sequence[MESH]|Biophysical Phenomena[MESH]|Biophysics[MESH]|Humans[MESH]|MicroRNAs/chemistry[MESH]|Models, Chemical[MESH]|Models, Genetic[MESH]|Molecular Sequence Data[MESH]|RNA Processing, Post-Transcriptional[MESH]|RNA, Double-Stranded/chemistry[MESH]|RNA, Small Interfering/metabolism[MESH]|RNA-Induced Silencing Complex/*physiology[MESH]|Thermodynamics[MESH]|Transcription, Genetic[MESH] |