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lüll Organometallic chemistry, biology and medicine: ruthenium arene anticancer complexes Yan YK; Melchart M; Habtemariam A; Sadler PJChem Commun (Camb) 2005[Oct]; ä (38): 4764-76Our work has shown that certain ruthenium(II) arene complexes exhibit promising anticancer activity in vitro and in vivo. The complexes are stable and water-soluble, and their frameworks provide considerable scope for optimising the design, both in terms of their biological activity and for minimising side-effects by variations in the arene and the other coordinated ligands. Initial studies on amino acids and nucleotides suggest that kinetic and thermodynamic control over a wide spectrum of reactions of Ru(II) arene complexes with biomolecules can be achieved. These Ru(II) arene complexes appear to have an altered profile of biological activity in comparison with metal-based anticancer complexes currently in clinical use or on clinical trial.|Antineoplastic Agents/chemical synthesis/*chemistry/pharmacology[MESH]|Benzene Derivatives/*chemistry[MESH]|DNA/drug effects[MESH]|Drug Design[MESH]|Humans[MESH]|Molecular Structure[MESH]|Organometallic Compounds/chemical synthesis/*chemistry/pharmacology[MESH]|Proteins/chemistry/drug effects[MESH]|Ruthenium/*chemistry[MESH]|Stereoisomerism[MESH]|Structure-Activity Relationship[MESH] |