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lüll bcr/abl-negative, classic myeloproliferative disorders: diagnosis and treatment Tefferi A; Barbui TMayo Clin Proc 2005[Sep]; 80 (9): 1220-32Essential thrombocythemia, polycythemia vera, and myelofibrosis with myeloid metaplasia constitute the "classic" bcr/abl-negative myeloproliferative disorders (MPDs). Each of these MPDs represents a stem cell-derived clonal myeloproliferation with the respective features of thrombocytosis, erythrocytosis, and bone marrow fibrosis. Unlike with cases of chronic myeloid leukemia, in which the bcr/abl mutation is invariably detected, current diagnosis of essential thrombocythemia, polycythemia vera, and myelofibrosis with myeloid metaplasia is based on a consensus-driven set of clinical and laboratory criteria that have undergone substantial modification in recent times. The recent discovery of a recurrent activating Janus tyrosine kinase (JAK2) mutation (JAK2VG17F) in all 3 classic MPDs offers another opportunity for refining current diagnoses and disease classifications. In this article, we outline contemporary diagnostic algorithms for each of these disorders and provide an evidence-based approach to management.|Erythropoietin/blood[MESH]|Genes, abl/genetics[MESH]|Humans[MESH]|Myeloproliferative Disorders/*diagnosis/genetics/*therapy[MESH]|Prognosis[MESH] |