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The chaperone-usher pathway of bacterial adhesin biogenesis -- from molecular mechanism to strategies of anti-bacterial prevention and modern vaccine design Piatek R; Zalewska B; Bury K; Kur JActa Biochim Pol 2005[]; 52 (3): 639-46The chaperone-usher system determines the biogenesis of surface-exposed adhesive structures responsible for virulence of many Gram-negative bacteria. Investigations of the last 20 years have resolved the mechanism of this pathway on a structural level for different species of pathogenic bacteria. The purpose of this review is to present the molecular mechanisms of the biogenesis of adhesive structures assembled via the chaperone-usher pathway. The obtained mechanistic data allow one to propose potential strategies of anti-bacterial action. Additionally, the specific properties of the polymeric adhesive structures (pili and fimbriae) of the chaperone-usher system allow their use as effective and safe recombinant vaccines carrying foreign epitopes in thousands of copies on bacterial cell surface.|*Drug Design[MESH]|Adhesins, Bacterial/metabolism[MESH]|Anti-Bacterial Agents/*chemistry/pharmacology[MESH]|Bacterial Infections/prevention & control[MESH]|Bacterial Proteins/chemistry/*metabolism[MESH]|Bacterial Vaccines/administration & dosage/*chemistry[MESH]|Cell Membrane/metabolism[MESH]|Epitopes/immunology[MESH]|Fimbriae Proteins/chemistry/metabolism[MESH]|Fimbriae, Bacterial/chemistry/metabolism[MESH]|Microbial Sensitivity Tests[MESH]|Molecular Chaperones/chemistry/*metabolism[MESH] |
