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Molecular pathways leading to cancer cachexia Tisdale MJPhysiology (Bethesda) 2005[Oct]; 20 (ä): 340-8Loss of body weight in cancer patients strongly influences morbidity and mortality. Recent studies have suggested that both tumor and host factors play a major role in tissue catabolism in cachexia, leading to upregulation of degradative pathways in both skeletal muscle and adipose tissue.|Adipose Tissue/metabolism[MESH]|Animals[MESH]|Blood Proteins/metabolism[MESH]|Cachexia/*etiology/metabolism[MESH]|Cytokines/metabolism[MESH]|Humans[MESH]|Muscle, Skeletal/metabolism[MESH]|Neoplasms/*complications/*metabolism[MESH]|Peptides/metabolism[MESH]|Proteoglycans[MESH] |
