Warning: Undefined variable $zfal in C:\Inetpub\vhosts\kidney.de\httpdocs\mlpefetch.php on line 525
Deprecated: str_replace(): Passing null to parameter #3 ($subject) of type array|string is deprecated in C:\Inetpub\vhosts\kidney.de\httpdocs\mlpefetch.php on line 525
Warning: Undefined variable $sterm in C:\Inetpub\vhosts\kidney.de\httpdocs\mlpefetch.php on line 530
free
Warning: Undefined variable $sterm in C:\Inetpub\vhosts\kidney.de\httpdocs\mlpefetch.php on line 531
free free
English Wikipedia
Nephropedia Template TP (
Twit Text
DeepDyve Pubget Overpricing |
lüll Mitochondrial ion channels: gatekeepers of life and death O'Rourke B; Cortassa S; Aon MAPhysiology (Bethesda) 2005[Oct]; 20 (ä): 303-15Continuous generation of ATP by mitochondrial oxidative phosphorylation is essential to maintain function in mechanically active cells such as cardiomyocytes. Emerging evidence indicates that mitochondrial ion channels activated by reactive oxygen species can induce a mitochondrial "critical" state, which can scale to cause electrical and contractile dysfunction of the cardiac cell and, ultimately, the whole heart. Here we focus on how mitochondrial ion channels participate in life-and-death decisions of the cell and discuss the challenges ahead for translating recent findings into novel therapeutic applications.|Animals[MESH]|Cell Survival/physiology[MESH]|Energy Metabolism[MESH]|Humans[MESH]|Ion Channels/*physiology[MESH]|Ischemia/physiopathology[MESH]|Mitochondria, Heart/*metabolism[MESH]|Myocardial Reperfusion Injury/prevention & control[MESH]|Myocytes, Cardiac/*physiology[MESH]|Reactive Oxygen Species/metabolism[MESH] |