Warning: Undefined variable $zfal in C:\Inetpub\vhosts\kidney.de\httpdocs\mlpefetch.php on line 525
Deprecated: str_replace(): Passing null to parameter #3 ($subject) of type array|string is deprecated in C:\Inetpub\vhosts\kidney.de\httpdocs\mlpefetch.php on line 525
Warning: Undefined variable $sterm in C:\Inetpub\vhosts\kidney.de\httpdocs\mlpefetch.php on line 530
Warning: Undefined variable $sterm in C:\Inetpub\vhosts\kidney.de\httpdocs\mlpefetch.php on line 531
English Wikipedia
Nephropedia Template TP (
Twit Text
DeepDyve Pubget Overpricing |
lüll Looking chloride channels straight in the eye: bestrophins, lipofuscinosis, and retinal degeneration Hartzell C; Qu Z; Putzier I; Artinian L; Chien LT; Cui YPhysiology (Bethesda) 2005[Oct]; 20 (ä): 292-302Recent evidence suggests that Cl(-) ion channels are important for retinal integrity. Bestrophin Cl(-) channel mutations in humans are genetically linked to a juvenile form of macular degeneration, and disruption of some ClC Cl(-) channels in mice leads to retinal degeneration. In both cases, accumulation of lipofuscin pigment is a key feature of the cellular degeneration. Because Cl(-) channels regulate the ionic environment inside organelles in the endosomal-lysosomal pathway, retinal degeneration may result from defects in lysosomal trafficking or function.|Animals[MESH]|Bestrophins[MESH]|Chloride Channels/genetics/*metabolism[MESH]|Eye Proteins/*metabolism[MESH]|Eye/*metabolism[MESH]|Humans[MESH]|Lipofuscin/metabolism[MESH]|Macular Degeneration/genetics[MESH]|Mutation[MESH]|Neuronal Ceroid-Lipofuscinoses/*metabolism[MESH]|Organelles/metabolism[MESH]|Retinal Degeneration/*metabolism[MESH] |