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lüll The prima donna of epigenetics: the regulation of gene expression by DNA methylation Santos KF; Mazzola TN; Carvalho HFBraz J Med Biol Res 2005[Oct]; 38 (10): 1531-41This review focuses on the mechanisms of DNA methylation, DNA methylation pattern formation and their involvement in gene regulation. Association of DNA methylation with imprinting, embryonic development and human diseases is discussed. Furthermore, besides considering changes in DNA methylation as mechanisms of disease, the role of epigenetics in general and DNA methylation in particular in transgenerational carcinogenesis, in memory formation and behavior establishment are brought about as mechanisms based on the cellular memory of gene expression patterns.|*DNA Methylation[MESH]|Animals[MESH]|Cell Differentiation/genetics[MESH]|CpG Islands/genetics[MESH]|Epigenesis, Genetic/*genetics/physiology[MESH]|Gene Expression Regulation[MESH]|Gene Silencing/*physiology[MESH]|Humans[MESH]|Inheritance Patterns/*genetics/physiology[MESH]|Memory[MESH]|Neoplasms/*genetics[MESH] |