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lüll The great MYC escape in tumorigenesis Dang CV; O'donnell KA; Juopperi TCancer Cell 2005[Sep]; 8 (3): 177-8Increased wild-type MYC expression occurs frequently in human cancers, except in Burkitt's lymphoma, where the translocated MYC allele is frequently mutated at several hotspots, including a major one at threonine-58. Acute MYC expression increases p53 or ARF levels and induces apoptosis, and previous transgenic animal studies revealed frequent inactivating mutations of p53 or p19ARF in transgenic Myc-induced lymphomas. Lowe and coworkers (Hemann et al., 2005) demonstrate that wild-type MYC can also trigger apoptosis by inducing Bim, which neutralizes Bcl-2. In contrast, the MYC point mutants failed to induce Bim, promoting murine lymphomas that escaped both wild-type p53 and p19ARF, and in doing so, evaded apoptosis.|*Genes, myc[MESH]|Animals[MESH]|Apoptosis[MESH]|Burkitt Lymphoma/genetics[MESH]|Gene Expression Regulation, Neoplastic[MESH]|Humans[MESH]|Lymphoma/genetics/pathology[MESH]|Models, Biological[MESH]|Mutation[MESH]|Neoplasms/*genetics/pathology[MESH] |