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  • Genome-wide application of RNAi to the discovery of potential drug targets
  • Ito M; Kawano K; Miyagishi M; Taira K
  • FEBS Lett 2005[Oct]; 579 (26): 5988-95
  • Progress is being made in the development of RNA interference-based (RNAi-based) strategies for the control of gene expression. It has been demonstrated that small interfering RNAs (siRNAs) can silence the expression of target genes in a sequence-specific manner in mammalian cells. Various groups, including our own, have developed systems for vector-mediated specific RNAi. Vector-based siRNA- (or shRNA) expression libraries directed against the entire human genome and siRNA libraries based on chemically synthesized oligonucleotides now allow the rapid identification of functional genes and potential drug targets. Use of such libraries will enhance our understanding of numerous biological phenomena and contribute to the rational design of drugs against heritable, infectious and malignant diseases.
  • |*Gene Expression Regulation[MESH]
  • |*Gene Silencing[MESH]
  • |*Genetic Techniques[MESH]
  • |*Genome, Human[MESH]
  • |*RNA Interference[MESH]
  • |Animals[MESH]
  • |Chemistry, Pharmaceutical[MESH]
  • |Drug Design[MESH]
  • |Gene Library[MESH]
  • |Genetic Vectors[MESH]
  • |Humans[MESH]
  • |Models, Genetic[MESH]
  • |Mutation[MESH]
  • |RNA, Small Interfering/metabolism[MESH]





  • *{{pmid16153642}}
    *<b>[http://www.kidney.de/mlpefetch.php?search=16153642 Genome-wide application of RNAi to the discovery of potential drug targets ]</b> FEBS Lett 2005; 579(26) ; 5988-95 Ito M; Kawano K; Miyagishi M; Taira K

        *16153642*

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    FEBS Lett

    5988 26.579 2005