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lüll CAMPATH: from concept to clinic Waldmann H; Hale GPhilos Trans R Soc Lond B Biol Sci 2005[Sep]; 360 (1461): 1707-11Lymphocyte depletion has a long history in the area of therapeutic immunosuppression. CAMPATH-1H (alemtuzumab) was generated in an attempt to replace anti-lymphocyte globulins in the transplant arena. Its efficacy in killing lymphocytes has established it as a licensed drug for the management of chronic lymphocyte leukaemia. Short-term therapy with alemtuzumab has demonstrated long-term benefit in a number of autoimmune conditions. This drug has the potential to facilitate recruitment of tolerance processes so enabling drug minimization in transplantation, autoimmune and hypersensitivity diseases.|*Models, Immunological[MESH]|Alemtuzumab[MESH]|Animals[MESH]|Antibodies, Monoclonal, Humanized[MESH]|Antibodies, Monoclonal/*immunology/therapeutic use[MESH]|Antibodies, Neoplasm/*immunology/*therapeutic use[MESH]|Graft vs Host Disease/*drug therapy/immunology[MESH]|Humans[MESH]|Immune Tolerance/*immunology[MESH]|Lymphocyte Depletion/*methods[MESH]|T-Lymphocytes/*immunology[MESH] |