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lüll Familial occurrence of Kawasaki syndrome in North America Dergun M; Kao A; Hauger SB; Newburger JW; Burns JCArch Pediatr Adolesc Med 2005[Sep]; 159 (9): 876-81OBJECTIVE: To describe families with multiple members affected with Kawasaki syndrome (KS) to increase awareness of the familial occurrence of KS among practitioners who care for these patients. DESIGN: Retrospective review of medical records at 2 medical centers and data collection from remote KS families who contacted the KS Research Program at the University of California, San Diego. RESULTS: Eighteen families with multiple affected members were identified. There were 9 families with 2 affected siblings. In San Diego, 3 (0.7%) of 424 KS families had sibling cases. Nine families were identified with KS in 2 generations or in multiple affected members, yielding a total of 24 KS-affected children. No clear pattern of inheritance could be deduced from these pedigrees, and it is likely that multiple polymorphic alleles influence KS susceptibility. CONCLUSION: Physicians should counsel affected families and make them aware of the potential increased risk of KS among family members.|*Pedigree[MESH]|Adolescent[MESH]|Asian People/genetics[MESH]|Asian/*genetics[MESH]|Boston/epidemiology[MESH]|California/epidemiology[MESH]|Child[MESH]|Child, Preschool[MESH]|Family/*ethnology[MESH]|Female[MESH]|Humans[MESH]|Infant[MESH]|Infant, Newborn[MESH]|Male[MESH]|Mexican Americans/genetics[MESH]|Mucocutaneous Lymph Node Syndrome/*epidemiology/*genetics[MESH]|North America/epidemiology[MESH]|Prevalence[MESH]|Risk Factors[MESH]|Siblings/ethnology[MESH]|White People/genetics[MESH] |