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lüll Sensitive determination of D-amino acids in mammals and the effect of D-amino-acid oxidase activity on their amounts Hamase K; Konno R; Morikawa A; Zaitsu KBiol Pharm Bull 2005[Sep]; 28 (9): 1578-84The determination of small amounts of D-amino acids in mammalian tissues is still a challenging theme in the separation sciences. In this review, various gas-chromatographic and high-performance liquid chromatographic methods are discussed including highly selective and sensitive column-switching procedures. Based on these methods, the distributions of D-aspartic acid, D-serine, D-alanine, D-leucine and D-proline have been clarified in the mouse brain. As the regulation mechanisms of D-amino acid amounts in mammals, we focused on the D-amino-acid oxidase, which catalyzes the degradation of D-amino acids. Using the mutant mouse strain lacking D-amino-acid oxidase activity, the effects of the enzymatic activity on the amounts and distributions of various D-amino acids have been investigated.|Amino Acids/*analysis/metabolism[MESH]|Animals[MESH]|Brain Chemistry/physiology[MESH]|Chromatography, High Pressure Liquid[MESH]|D-Amino-Acid Oxidase/genetics/*metabolism[MESH]|Humans[MESH]|Mammals/*metabolism[MESH]|Mice[MESH]|Mice, Knockout[MESH] |