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lüll Coincidence detection in phosphoinositide signaling Carlton JG; Cullen PJTrends Cell Biol 2005[Oct]; 15 (10): 540-7Phosphoinositide lipids function as both signaling molecules and as compartment-specific localization signals for phosphoinositide-binding proteins. In recent years, both phosphoinositides and phosphoinositide-binding proteins have been reported to display a restricted, rather than a uniform, distribution across intracellular membranes. Here, we examine recent data documenting the restricted distribution of both phosphoinositides and phosphoinositide-binding proteins and examine how phosphoinositide-binding proteins might engage multiple binding partners to achieve these restricted localizations, effectively acting as detectors of coincident localization signals.|Enzyme Activation[MESH]|Lipid Metabolism[MESH]|Lipids/chemistry[MESH]|Membrane Microdomains[MESH]|Models, Molecular[MESH]|Molecular Structure[MESH]|Phosphatidylinositols/*chemistry/*metabolism[MESH]|Second Messenger Systems/*physiology[MESH] |