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lüll The therapeutic potential of RNA interference Uprichard SLFEBS Lett 2005[Oct]; 579 (26): 5996-6007In recent years, we have witnessed the discovery of a new mechanism of gene regulation called RNA interference (RNAi), which has revitalized interest in the development of nucleic acid-based technologies for therapeutic gene suppression. This review focuses on the potential therapeutic use of RNAi, discussing the theoretical advantages of RNAi-based therapeutics over previous technologies as well as the challenges involved in developing RNAi for clinical use. Also reviewed, are the in vivo proof-of principle experiments that provide the preclinical justification for the continued development of RNAi-based therapeutics.|*Drug Delivery Systems[MESH]|*Gene Expression Regulation[MESH]|*RNA Interference[MESH]|Animals[MESH]|Antineoplastic Agents/pharmacology[MESH]|Apoptosis[MESH]|Biotechnology[MESH]|Drug Industry[MESH]|Eye Diseases/therapy[MESH]|Gene Expression Regulation, Viral[MESH]|Genetic Techniques[MESH]|Humans[MESH]|Inflammation/therapy[MESH]|RNA, Small Interfering/metabolism[MESH]|RNA, Viral/*genetics[MESH] |