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lüll Structural domains in RNAi Collins RE; Cheng XFEBS Lett 2005[Oct]; 579 (26): 5841-9Structural and biochemical studies have begun to elucidate the pathway of RNA silencing that leads to the formation of the RISC complex. The outstanding feature of this pathway is the precise recognition and processing of double-stranded RNA. We present a review of recent structures that illustrate the molecular mechanisms contributing to these two related functions, highlighting models of Drosha, Dicer, and RISC function.|*RNA Interference[MESH]|Animals[MESH]|Binding Sites[MESH]|Catalytic Domain[MESH]|Crystallography, X-Ray[MESH]|Gene Silencing[MESH]|Genetic Techniques[MESH]|Humans[MESH]|MicroRNAs/chemistry[MESH]|Models, Molecular[MESH]|Protein Conformation[MESH]|Protein Structure, Tertiary[MESH]|Pyrococcus/metabolism[MESH]|RNA, Double-Stranded/chemistry[MESH]|RNA-Induced Silencing Complex/physiology[MESH]|RNA/*chemistry[MESH]|Ribonuclease H/chemistry[MESH]|Ribonuclease III/*chemistry/physiology[MESH] |