Warning: Undefined variable $zfal in C:\Inetpub\vhosts\kidney.de\httpdocs\mlpefetch.php on line 525
Deprecated: str_replace(): Passing null to parameter #3 ($subject) of type array|string is deprecated in C:\Inetpub\vhosts\kidney.de\httpdocs\mlpefetch.php on line 525
Warning: Undefined variable $sterm in C:\Inetpub\vhosts\kidney.de\httpdocs\mlpefetch.php on line 530
Warning: Undefined variable $sterm in C:\Inetpub\vhosts\kidney.de\httpdocs\mlpefetch.php on line 531
 
English Wikipedia
Nephropedia Template TP (
Twit Text
DeepDyve
Pubget Overpricing |  
lüll
Pathophysiology of the antiphospholipid syndrome de Groot PG; Derksen RHJ Thromb Haemost 2005[Aug]; 3 (8): 1854-60Antiphospholipid syndrome is a distinct disorder with the clinical features of recurrent thrombosis in the venous or arterial circulation and fetal losses. Its serological marker is the presence of antiphospholipid antibodies in the blood of these patients. The relation between the presence of antibodies against anionic phospholipids and thromboembolic complications is well established over the last 25 years but the pathophysiology of the syndrome is largely unclear. Even after all these years, there is a persisting debate about the specificity and sensitivity of the assays for the detection of antiphospholipid antibodies. We now accept that antibodies to beta2-glycoprotein I rather than to anionic phospholipids are the major pathological antibodies, although there is no clear consensus on how the presence of these antibodies correlates with the different clinical manifestations of the syndrome. In this review, we discuss the current methods of detection of the antibodies and our insight into the pathobiology of the syndrome. We propose a mechanism for describing how the presence of anti-beta2-glycoprotein I antibodies relates to the different clinical manifestations observed.|Antibodies, Antiphospholipid/*blood[MESH]|Antiphospholipid Syndrome/*diagnosis/*immunology/pathology[MESH]|Blood Platelets/metabolism[MESH]|Crystallography, X-Ray[MESH]|Enzyme-Linked Immunosorbent Assay[MESH]|Female[MESH]|Glycoproteins/immunology[MESH]|Humans[MESH]|MAP Kinase Signaling System[MESH]|Models, Biological[MESH]|Models, Molecular[MESH]|Pregnancy[MESH]|Pregnancy Complications, Hematologic/diagnosis/pathology[MESH]|beta 2-Glycoprotein I[MESH] |
