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lüll Mastocytosis and adverse reactions to biogenic amines and histamine-releasing foods: what is the evidence?Vlieg-Boerstra BJ; van der Heide S; Oude Elberink JN; Kluin-Nelemans JC; Dubois AENeth J Med 2005[Jul]; 63 (7): 244-9BACKGROUND: It has been suggested that normal concentrations of biogenic amines and 'histamine-releasing foods' may exacerbate symptoms in mastocytosis. The purpose of this study was to look for scientific evidence in the literature on diets restricted in biogenic amines and histamine-releasing foods in the treatment of mastocytosis. METHODS: Medline (1966 to 2004), Cinahl (1982 to 2004) and the Cochraine Library were searched for double-blind placebo-controlled food challenge (DBPCFC) studies with biogenic amines and/or histamine-releasing foods in mastocytosis. RESULTS: No studies employing DBPCFC with dietary biogenic amines or histamine-releasing foods in mastocytosis were found. Only a few in vitro studies in other diseases, animal studies and studies in humans in which histamine-releasing agents were incubated directly with duodenal tissues were found. One case was reported of severe adverse reactions to alcohol in mastocytosis, objectified by an open challenge. CONCLUSION: Despite the widespread belief that biogenic amines and histamine-releasing foods may cause allergy-like, non-IgE-mediated symptoms in certain patients, the role of diets restricted in biogenic amines and histamine-releasing foods in the treatment of mastosytosis remains hypothetical but worthy of further investigation. There is some evidence for adverse reactions to alcohol in mastocytosis.|*Food Contamination/analysis[MESH]|Animals[MESH]|Biogenic Amines/*adverse effects/analysis[MESH]|Eggs/analysis[MESH]|Histamine/*adverse effects/analysis[MESH]|Humans[MESH]|Mastocytosis/*chemically induced[MESH]|Methylhistamines/*adverse effects/analysis[MESH]|Shellfish/analysis[MESH]|Wine/analysis[MESH] |