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lüll CD4+CD25+-regulatory T cells from mouse to man Wing K; Suri-Payer E; Rudin AScand J Immunol 2005[Jul]; 62 (1): 1-15Immunological tolerance is one of the fundamental concepts of the immune system. During the past decade, CD4+CD25+-regulatory T cells have emerged as key players in the development of tolerance to autoantigens as well as to foreign antigens. Still many questions remain illusive regarding the basic properties of CD4+CD25+-regulatory T cells. This review aims to recapitulate some of the current understandings about the phenotype, function and clinical relevance of murine and human CD4+CD25+-regulatory T cells.|Animals[MESH]|Autoimmune Diseases/immunology[MESH]|CD4-Positive T-Lymphocytes/*immunology[MESH]|Humans[MESH]|Hypersensitivity/immunology[MESH]|Immune Tolerance/*immunology[MESH]|Mice[MESH]|Neoplasms/immunology[MESH]|Phenotype[MESH]|Receptors, Interleukin-2/*analysis/immunology[MESH] |