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Macrophage fusion: the making of osteoclasts and giant cells Vignery AJ Exp Med 2005[Aug]; 202 (3): 337-40The fusion of cells is a fundamental biological event that is essential for a variety of developmental and homeostatic processes. Fusion is required for the formation of multinucleated osteoclasts and giant cells, although the mechanisms that govern these processes are poorly understood. A new study now reveals an unexpected role for the receptor, dendritic cell-specific transmembrane protein (DC-STAMP), in this process. The potential mechanism by which DC-STAMP governs fusion and the implications of this finding will be discussed.|Adaptor Proteins, Signal Transducing[MESH]|Animals[MESH]|Cell Fusion[MESH]|Giant Cells/*physiology[MESH]|Humans[MESH]|Macrophages/*physiology[MESH]|Membrane Proteins/*metabolism[MESH]|Osteoclasts/*physiology[MESH] |
