Warning: Undefined variable $zfal in C:\Inetpub\vhosts\kidney.de\httpdocs\mlpefetch.php on line 525
Deprecated: str_replace(): Passing null to parameter #3 ($subject) of type array|string is deprecated in C:\Inetpub\vhosts\kidney.de\httpdocs\mlpefetch.php on line 525
Warning: Undefined variable $sterm in C:\Inetpub\vhosts\kidney.de\httpdocs\mlpefetch.php on line 530
Warning: Undefined variable $sterm in C:\Inetpub\vhosts\kidney.de\httpdocs\mlpefetch.php on line 531
English Wikipedia
Nephropedia Template TP (
Twit Text
DeepDyve Pubget Overpricing |
lüll AMP-activated protein kinase: ancient energy gauge provides clues to modern understanding of metabolism Kahn BB; Alquier T; Carling D; Hardie DGCell Metab 2005[Jan]; 1 (1): 15-25The AMP-activated protein kinase (AMPK) is an evolutionarily conserved sensor of cellular energy status, and recent data demonstrate that it also plays a critical role in systemic energy balance. AMPK integrates nutritional and hormonal signals in peripheral tissues and the hypothalamus. It mediates effects of adipokines (leptin, adiponectin, and possibly resistin) in regulating food intake, body weight, and glucose and lipid homeostasis. AMPK is regulated by upstream kinases of which the tumor suppressor, LKB1, is the first to be identified. Complex signaling networks suggest that AMPK may prevent insulin resistance, in part by inhibiting pathways that antagonize insulin signaling. Through signaling, metabolic, and gene expression effects, AMPK enhances insulin sensitivity and fosters a metabolic milieu that may reduce the risk for obesity and type 2 diabetes.|AMP-Activated Protein Kinases[MESH]|Adaptor Proteins, Signal Transducing/metabolism[MESH]|Animals[MESH]|Body Weight[MESH]|Disease Models, Animal[MESH]|Exercise[MESH]|Homeostasis[MESH]|Hormones, Ectopic/metabolism[MESH]|Humans[MESH]|Insulin/metabolism[MESH]|Mice[MESH]|Models, Biological[MESH]|Multienzyme Complexes/genetics/metabolism/*physiology[MESH]|Mutation[MESH]|Physical Conditioning, Animal[MESH]|Protein Serine-Threonine Kinases/genetics/metabolism/*physiology[MESH]|Resistin[MESH]|Signal Transduction[MESH] |