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Signaling interplay in Ras superfamily function Mitin N; Rossman KL; Der CJCurr Biol 2005[Jul]; 15 (14): R563-74Ras proteins function as signaling hubs that are activated by convergent signaling pathways initiated by extracellular stimuli. Activated Ras in turn regulates a diversity of downstream cytoplasmic signaling cascades. Ras proteins are founding members of a large superfamily of small GTPases that have significant sequence and biochemical similarities. Recent observations have established a complex signaling interplay between Ras and other members of the family. A key biochemical mechanism facilitating this crosstalk involves guanine nucleotide exchange factors (GEFs), which serve as regulators and effectors, as well as signaling integrators, of Ras signaling.|*Models, Biological[MESH]|Cytoplasm/*metabolism[MESH]|GTPase-Activating Proteins/*metabolism[MESH]|Gene Components[MESH]|Guanine Nucleotide Exchange Factors/*metabolism[MESH]|Humans[MESH]|Second Messenger Systems/*physiology[MESH]|Signal Transduction/*physiology[MESH]|ras Proteins/metabolism/*physiology[MESH] |
