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lüll Neurodegenerative disorders: Parkinson s disease and Huntington s disease Hague SM; Klaffke S; Bandmann OJ Neurol Neurosurg Psychiatry 2005[Aug]; 76 (8): 1058-63Parkinson's disease and Huntington's disease are both model diseases. Parkinson's disease is the most common of several akinetic-rigid syndromes and Huntington's disease is only one of an ever growing number of trinucleotide repeat disorders. Molecular genetic studies and subsequent molecular biological studies have provided fascinating new insights into the pathogenesis of both disorders and there is now real hope for disease modifying treatment in the not too distant future for patients with Parkinson's disease or Huntington's disease.|Aged[MESH]|Aged, 80 and over[MESH]|Alleles[MESH]|Animals[MESH]|Gene Expression/genetics[MESH]|Humans[MESH]|Huntington Disease/genetics/metabolism/*physiopathology[MESH]|Mice[MESH]|Microglia/metabolism[MESH]|Middle Aged[MESH]|Nerve Tissue Proteins/genetics/metabolism[MESH]|Neurodegenerative Diseases/genetics/metabolism/*physiopathology[MESH]|Parkinson Disease/genetics/metabolism/*physiopathology[MESH]|Parkinsonian Disorders/physiopathology[MESH]|Proteasome Endopeptidase Complex/metabolism[MESH]|Proteomics/methods[MESH]|Synucleins[MESH]|Trinucleotide Repeats/genetics[MESH]|Ubiquitin-Protein Ligases/genetics/metabolism[MESH] |