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Lung transplantation: opportunities for research and clinical advancement Wilkes DS; Egan TM; Reynolds HYAm J Respir Crit Care Med 2005[Oct]; 172 (8): 944-55Lung transplantation is the only definitive therapy for many forms of end-stage lung diseases. However, the success of lung transplantation is limited by many factors: (1) Too few lungs available for transplantation due to limited donors or injury to the donor lung; (2) current methods of preservation of excised lungs do not allow extended periods of time between procurement and implantation; (3) acute graft failure is more common with lungs than other solid organs, thus contributing to poorer short-term survival after lung transplant compared with that for recipients of other organs; (4) lung transplant recipients are particularly vulnerable to pulmonary infections; and (5) chronic allograft dysfunction, manifest by bronchiolitis obliterans syndrome, is frequent and limits long-term survival. Scientific advances may provide significant improvements in the outcome of lung transplantation. The National Heart, Lung, and Blood Institute convened a working group of investigators on June 14-15, 2004, in Bethesda, Maryland, to identify opportunities for scientific advancement in lung transplantation, including basic and clinical research. This workshop provides a framework to identify critical issues related to clinical lung transplantation, and to delineate important areas for productive scientific investigation.|*Lung Transplantation/adverse effects/immunology/statistics & numerical data[MESH]|Acute Disease[MESH]|Antibody Formation/immunology[MESH]|Autoimmunity/immunology[MESH]|Bronchiolitis Obliterans/epidemiology/etiology/prevention & control[MESH]|Chemokines/immunology[MESH]|Chronic Disease[MESH]|Cross Infection/epidemiology/etiology/prevention & control[MESH]|Graft Rejection/epidemiology/etiology/prevention & control[MESH]|Graft Survival[MESH]|Health Planning Guidelines[MESH]|Humans[MESH]|Immunosuppression Therapy/*methods/standards[MESH]|Needs Assessment[MESH]|Patient Selection[MESH]|Perioperative Care/*organization & administration[MESH]|Research/*organization & administration[MESH]|T-Lymphocytes, Regulatory/immunology[MESH]|Tissue and Organ Procurement/*organization & administration[MESH]|Transplantation Tolerance[MESH]|Treatment Outcome[MESH]|United States/epidemiology[MESH]|Waiting Lists[MESH] |
