Warning: Undefined variable $zfal in C:\Inetpub\vhosts\kidney.de\httpdocs\mlpefetch.php on line 525
Deprecated: str_replace(): Passing null to parameter #3 ($subject) of type array|string is deprecated in C:\Inetpub\vhosts\kidney.de\httpdocs\mlpefetch.php on line 525
Warning: Undefined variable $sterm in C:\Inetpub\vhosts\kidney.de\httpdocs\mlpefetch.php on line 530
 free
Warning: Undefined variable $sterm in C:\Inetpub\vhosts\kidney.de\httpdocs\mlpefetch.php on line 531
 free
 free
 
English Wikipedia
Nephropedia Template TP (
Twit Text
DeepDyve
Pubget Overpricing |  
lüll
Therapeutic potential of wogonin: a naturally occurring flavonoid Tai MC; Tsang SY; Chang LY; Xue HCNS Drug Rev 2005[Sum]; 11 (2): 141-50The search for flavonoids with novel therapeutic effects has been intense. Wogonin, as a naturally existing monoflavonoid, has been shown to have therapeutic potential in vitro and in vivo. Methods for its extraction from herbs and its chemical synthesis have been developed. Pharmacokinetic studies have shown a rapid tissue distribution and prolonged plasma elimination phase of wogonin. It has been shown experimentally that wogonin exerts anti-oxidant activity, which may, in part, underlie its antiinflammatory, anti-cancer, antiviral and neuroprotective actions. The recent discovery of its anxiolytic activity suggests a new mechanism of action, involving interaction with the benzodiazepine (BZD) binding site of the GABA(A) receptor and modulation of this receptor activity. Although the safety record of wogonin is remarkable and voluminous literature about its pharmacological effects is available, it has not been used in Western medicine in the form of a pure chemical. In this article we review its therapeutic effects, its sources and pharmacokinetic profile to highlight its therapeutic potential.|*Drugs, Chinese Herbal[MESH]|Animals[MESH]|Antioxidants/chemistry/pharmacology/therapeutic use[MESH]|Binding Sites/drug effects[MESH]|Drug Evaluation[MESH]|Flavanones/chemistry/history/pharmacology/*therapeutic use[MESH]|Flavonoids/pharmacology/therapeutic use[MESH]|History, Ancient[MESH]|Humans[MESH]|Inflammation/drug therapy[MESH]|Neoplasms/drug therapy[MESH]|Plant Extracts[MESH]|Receptors, GABA-A/metabolism[MESH]|Virus Diseases/drug therapy[MESH] |
