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Antiphospholipid syndrome: review Sammaritano LRSouth Med J 2005[Jun]; 98 (6): 617-25; quiz 626-7, 645Antiphospholipid syndrome spans many medical disciplines. Classic criteria include the presence of anticardiolipin antibody or lupus anticoagulant with typical complications of thrombosis or pregnancy loss. Other common associated manifestations include livedo reticularis, thrombocytopenia, valvular heart disease, and nephropathy with renal insufficiency, hypertension, and proteinuria. Treatment of serious complications with anticoagulation is standard; generally warfarin for thrombosis and aspirin/heparin for pregnancy prophylaxis. Detailed recommendations regarding precise intensity and duration of anticoagulation are still a subject of debate.|Antibodies, Antiphospholipid/analysis[MESH]|Anticoagulants/therapeutic use[MESH]|Antiphospholipid Syndrome/complications/*diagnosis/drug therapy[MESH]|Female[MESH]|Humans[MESH]|Lupus Coagulation Inhibitor/analysis[MESH]|Pregnancy[MESH]|Pregnancy Complications[MESH]|Pregnancy Outcome[MESH] |
