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Progressive systemic sclerosis complicated with immune thrombocytopenia during D-penicillamine therapy Natsuda H; Matsui Y; Sakauchi M; Kato S; Takemura H; Suzuki H; Kono I; Yamane K; Kashiwagi HIntern Med 1992[Feb]; 31 (2): 244-5Immune thrombocytopenia is a rare complication of progressive systemic sclerosis (PSS). A 47-year-old female with PSS treated with D-penicillamine developed immune thrombocytopenia, which promptly responded to prednisolone and withdrawal of D-penicillamine. Platelet-associated IgG was elevated and the bone marrow megakaryocyte count was normal. There was an inverse relationship between the level of platelet-associated IgG and the platelet count. A lymphocyte stimulation test sensitized by D-penicillamine was positive. The present case suggests that immune thrombocytopenia may be regarded as one of the D-penicillamine-related immune abnormalities. To our knowledge, its association with PSS has never been reported.|Blood Platelets/immunology[MESH]|Female[MESH]|Humans[MESH]|Immunoglobulin G/blood[MESH]|Middle Aged[MESH]|Penicillamine/*adverse effects/immunology[MESH]|Scleroderma, Systemic/*complications/drug therapy[MESH]|Thrombocytopenia/chemically induced/*etiology/immunology[MESH] |
