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lüll Septins: traffic control at the cytokinesis intersection Joo E; Tsang CW; Trimble WSTraffic 2005[Aug]; 6 (8): 626-34The physical division of one cell into two requires the highly orchestrated separation of genetic and cytoplasmic contents during M phase of the cell cycle. Mitosis, the physical segregation of the genetic material of a cell into two daughter cells, has traditionally received more attention than cytokinesis, the partitioning of the cytoplasmic contents, yet clearly the two processes must be intimately co-ordinated and tightly regulated. While plant cells divide by the formation of a membranous cell barrier called the phragmoplast, animal cell division is largely driven by contraction of an actomyosin ring. However, recent evidence has suggested that membranes derived from one or more intracellular compartments are also required to break the cytoplasmic bridge connecting two dividing cells during late telophase. In this review, we focus on studies of animal cell cytokinesis that support a requirement for specific endomembrane fusion during fission, define molecular components of the membrane fusion apparatus that may be involved and point to possible roles for an emerging family of cytoskeletal proteins, the septins, in this process.|Animals[MESH]|Cytokinesis/*physiology[MESH]|Cytoskeletal Proteins/*metabolism[MESH]|GTP Phosphohydrolases/*metabolism[MESH]|HeLa Cells[MESH]|Humans[MESH]|Intracellular Membranes/*metabolism[MESH]|Membrane Fusion/physiology[MESH]|Protein Transport[MESH]|SNARE Proteins[MESH]|Septins[MESH]|Vesicular Transport Proteins/*metabolism[MESH] |