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Mammalian sterile 20-like kinases in tumor suppression: an emerging pathway O'Neill EE; Matallanas D; Kolch WCancer Res 2005[Jul]; 65 (13): 5485-7Emerging evidence suggests that the proapoptotic kinase mammalian sterile 20-like kinase 2 (MST2) acts in a novel tumor suppression pathway. Recently, we showed that Raf-1 kinase sequesters and inhibits MST2 and that this event is critical for Raf-mediated cell survival. In this review, we summarize Raf control of MST2 and we outline a novel pathway involving the downstream effector proteins Salvador and Warts/Lats that may act to limit the positive effects of Raf-mitogen-activated protein kinase signaling in cancer cells.|Animals[MESH]|Apoptosis/physiology[MESH]|Humans[MESH]|Intracellular Signaling Peptides and Proteins[MESH]|Neoplasms/*enzymology/pathology[MESH]|Protein Serine-Threonine Kinases/*metabolism[MESH]|Proto-Oncogene Proteins c-raf/metabolism[MESH]|Serine-Threonine Kinase 3[MESH] |
