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Computed tomographic imaging of the airways: relationship to structure and function de Jong PA; Muller NL; Pare PD; Coxson HOEur Respir J 2005[Jul]; 26 (1): 140-52Alterations in the structure of the airways, collectively termed airway remodelling, contribute to airflow obstruction in a variety of chronic lung diseases. While histology has provided valuable insights into the structure of airway wall remodelling, this technique is invasive and does not allow the longitudinal analysis of airway wall dimensions. Technical advances in computed tomography allow the assessment of airway wall dimensions, and are ideally suited for the noninvasive investigation of the pathogenesis of airway wall remodelling and the evaluation of new therapeutic interventions. The aim of this article is to review the use of computed tomography in the investigation of airway structure and function in health and disease.|*Image Processing, Computer-Assisted[MESH]|*Tomography, X-Ray Computed[MESH]|Airway Obstruction/*diagnostic imaging/pathology[MESH]|Airway Resistance[MESH]|Asthma/*diagnostic imaging/physiopathology[MESH]|Bronchi/pathology[MESH]|Female[MESH]|Humans[MESH]|Male[MESH]|Pulmonary Disease, Chronic Obstructive/*diagnostic imaging/physiopathology[MESH]|Sensitivity and Specificity[MESH]|Severity of Illness Index[MESH] |
