suck pdf from google scholar
PDF vom PMID15969678  :  Publisher
PDF vom PMID15969678
suck pdf from library genesis
English Wikipedia

Nephropedia Template TP (

Twit Text

  • DeepDyve
  • Pubget Overpricing

  • lüll
  • CD4CD25 regulatory T lymphocytes in allergy and asthma
  • Shi HZ; Qin XJ
  • Allergy 2005[Aug]; 60 (8): 986-95
  • Allergic asthma is characterized by airway hyper-responsiveness and chronic mucosal inflammation mediated by CD4(+) Th2 lymphocytes. Regulatory CD4(+)CD25(+) T cells are important components of the homeostasis of the immune system, as impaired CD4(+)CD25(+) T cell activity can cause autoimmune diseases and allergy. The mechanism of suppression by CD4(+)CD25(+) T cells remains controversial; different in vivo and in vitro studies raise possible roles for the immunosuppressive cytokines interleukin-10 and transforming growth factor-beta, forkhead transcription factor Foxp3, glucocorticoid-induced tumor necrosis factor receptor, cytotoxic lymphocyte associated antigen-4, 4-1BB costimulator receptor, a CD4-related molecule LAG-3, and neuropilin-1. Current data suggest that Th2 responses to allergens are normally suppressed by CD4(+)CD25(+) T cells. Suppression by CD4(+)CD25(+) T cells is decreased in allergic individuals. Furthermore, CD4(+)CD25(+) T cells play a key role in regulating airway eosinophilic inflammation. The immunomodulatory properties of CD4(+)CD25(+) T cells do extend to Th2 responses, most notably by limiting the development of a proinflammatory CD4(+) Th2 phenotype characterized by reduced cytokine production. An understanding of the roles of CD4(+)CD25(+) T cells in vivo could provide better insight into the design of novel approaches to modulate the chronic airway inflammatory reaction evident in bronchial asthma.
  • |Asthma/*physiopathology[MESH]
  • |CD4-Positive T-Lymphocytes/*metabolism[MESH]
  • |Humans[MESH]
  • |Hypersensitivity/*physiopathology[MESH]
  • |Receptors, Interleukin-2/*metabolism[MESH]

  • *{{pmid15969678}}
    *<b>[ CD4CD25 regulatory T lymphocytes in allergy and asthma ]</b> Allergy 2005; 60(8) ; 986-95 Shi HZ; Qin XJ


    Nephropedia PMID record

    Deutsche Wikipedia - im Artikel

    Hier den unten stehenden Textblock hineinkopieren


    986 8.60 2005