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lüll Hyperbaric oxygen as an adjunctive treatment for zygomycosis John BV; Chamilos G; Kontoyiannis DPClin Microbiol Infect 2005[Jul]; 11 (7): 515-7Zygomycosis is a rare but emerging mycosis. Because of the sub-optimal efficacy of the standard antifungal treatment for this disease, hyperbaric oxygen (HBO) has been used occasionally as an adjunctive therapeutic modality. A review of 28 published cases of zygomycosis indicates that adjunctive HBO may be beneficial in diabetic patients (94% survival), whereas its benefit in the small group of patients with haematological malignancies or bone marrow transplants is doubtful (33% survival; p 0.02). Prolonged courses of HBO were associated with a higher survival (100% survival; p 0.003). Additional studies are required to assess the optimal timing and dose for HBO treatment.|*Hyperbaric Oxygenation[MESH]|Adolescent[MESH]|Adult[MESH]|Aged[MESH]|Child[MESH]|Child, Preschool[MESH]|Diabetes Complications/therapy[MESH]|Hematologic Neoplasms/complications/microbiology[MESH]|Humans[MESH]|Infant[MESH]|Male[MESH]|Middle Aged[MESH]|Mucorales[MESH]|Treatment Outcome[MESH]|Zygomycosis/complications/*therapy[MESH] |