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Histone modifications: from genome-wide maps to functional insights van Leeuwen F; van Steensel BGenome Biol 2005[]; 6 (6): 113A large number of histone modifications has been implicated in the regulation of gene expression. Together, these modifications have the potential to form a complex combinatorial regulatory code. Genome-wide mapping approaches provide new opportunities to decipher this code, but they may suffer from systematic biases. Integration of datasets and improved technologies will provide the way forward.|Acetylation[MESH]|Animals[MESH]|Gene Expression Regulation[MESH]|Genome/*genetics[MESH]|Histones/*metabolism[MESH]|Humans[MESH]|Models, Biological[MESH]|Nucleosomes/genetics/metabolism[MESH] |
