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lüll Signalling mechanisms underlying subversion of the immune response by the filarial nematode secreted product ES-62 Goodridge HS; Stepek G; Harnett W; Harnett MMImmunology 2005[Jul]; 115 (3): 296-304Secretion of immunomodulatory molecules is a key strategy employed by pathogens to enable their survival in host organisms. For example, arthropod-transmitted filarial nematodes, which achieve longevity within the infected host by suppressing and modulating the host immune response, produce excretory-secretory (ES) products that have been demonstrated to possess immunomodulatory properties. In this review we discuss the immunomodulatory effects of the phosphorylcholine-containing filarial nematode-secreted glycoprotein ES-62 and describe the intracellular signal transduction pathways it targets to achieve these effects.|Animals[MESH]|Antibody Formation/immunology[MESH]|B-Lymphocytes/immunology[MESH]|Filariasis/immunology[MESH]|Filarioidea/*immunology[MESH]|Glycoproteins/immunology[MESH]|Helminth Proteins/*immunology[MESH]|Humans[MESH]|Macrophages/immunology[MESH]|Phosphorylcholine/immunology[MESH]|Signal Transduction/*immunology[MESH]|T-Lymphocytes/immunology[MESH] |