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Is the cerebellum relevant in the circuitry of neuropsychiatric disorders?Konarski JZ; McIntyre RS; Grupp LA; Kennedy SHJ Psychiatry Neurosci 2005[May]; 30 (3): 178-86Contemporary mechanistic models of several psychiatric disorders propose abnormalities in the structure and function of distinct neural networks. The cerebellum has both anatomic and functional connections to the prefrontal cortex, the subcortical limbic structures and monoamine-producing brainstem nuclei. Conspicuously, however, the cerebellum has been underemphasized in neuropsychiatric research. A growing confluence of scientific data indicate that the cerebellum may not be irrelevant, which suggests that an integrated model of neuropsychiatric disorders should include a role for the cerebellum and its relevant neural connections. This review summarizes the published data describing and characterizing the putative role of the cerebellum in normal and abnormal mood regulation, with specific attention to states of psychosis, depression and mania. The available evidence suggests that a functional role for the cerebellum should be considered in future neuropsychiatric studies.|Bipolar Disorder/pathology/physiopathology[MESH]|Cerebellum/pathology/*physiopathology[MESH]|Depressive Disorder, Major/pathology/physiopathology[MESH]|Humans[MESH]|Mental Disorders/pathology/*physiopathology/psychology[MESH]|Nerve Net/pathology/*physiopathology[MESH]|Nervous System Diseases/pathology/*physiopathology/psychology[MESH]|Schizophrenia/pathology/physiopathology[MESH] |
