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lüll The anticoagulant protein C pathway Dahlback B; Villoutreix BOFEBS Lett 2005[Jun]; 579 (15): 3310-6The anticoagulant protein C system regulates the activity of coagulation factors VIIIa and Va, cofactors in the activation of factor X and prothrombin, respectively. Protein C is activated on endothelium by the thrombin-thrombomodulin-EPCR (endothelial protein C receptor) complex. Activated protein C (APC)-mediated cleavages of factors VIIIa and Va occur on negatively charged phospholipid membranes and involve protein cofactors, protein S and factor V. APC also has anti-inflammatory and anti-apoptotic activities that involve binding of APC to EPCR and cleavage of PAR-1 (protease-activated receptor-1). Genetic defects affecting the protein C system are the most common risk factors of venous thrombosis. The protein C system contains multi-domain proteins, the molecular recognition of which will be reviewed.|Animals[MESH]|Anticoagulants/chemistry/*metabolism[MESH]|Blood Coagulation[MESH]|Endothelium/cytology/drug effects/enzymology[MESH]|Humans[MESH]|Protein C/chemistry/*metabolism[MESH]|Protein S/metabolism[MESH]|Vitamin K/metabolism/pharmacology[MESH] |