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lüll Adeno-associated virus vector-mediated gene delivery to the vasculature and kidney Kapturczak MH; Chen S; Agarwal AActa Biochim Pol 2005[]; 52 (2): 293-9Relatively successful elsewhere, gene delivery aimed at the vasculature and kidney has made very little progress. In the kidney, the hurdles are related to the unique structure-function relationships of this organ and in the blood vessels to a variety of, mostly endothelial, factors making the delivery of transgenes very difficult. Among gene-therapeutic approaches, most viral gene delivery systems utilized to date have shown significant practical and safety-related limitations due to the level and duration of recombinant transgene expression as well as their induction of a significant host immune response to vector proteins. Recombinant adeno-associated virus (rAAV) vectors appear to offer a vehicle for safe, long-term transgene expression. rAAV-based vectors are characterized by a relative non-immunogenicity and the absence of viral coding sequences. Furthermore, they allow for establishment of long-term latency without deleterious effects on the host cell. This brief review addresses problems related to transgene-delivery to kidney and vasculature with particular attention given to rAAV vectors. The potential for gene therapy as a strategy for selected renal and vascular diseases is also discussed.|Animals[MESH]|Dependovirus/genetics/*physiology[MESH]|Endothelium, Vascular/*metabolism[MESH]|Gene Transfer Techniques[MESH]|Genetic Vectors/genetics/*physiology[MESH]|Humans[MESH]|Kidney/*metabolism[MESH] |