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lüll Tumor dormancy and MYC inactivation: pushing cancer to the brink of normalcy Shachaf CM; Felsher DWCancer Res 2005[Jun]; 65 (11): 4471-4Upon MYC inactivation, tumors variously undergo proliferative arrest, cellular differentiation, and apoptosis and in some cases, apparently permanently revoking tumorigenesis. In liver tumor cells, we recently showed that MYC inactivation uncovers stem cell properties and triggers differentiation, but in this case, their neoplastic properties are restorable by MYC reactivation. Thus, whereas oncogene inactivation can push cancer to the brink of normalcy, some cells retain the latent capacity to turn cancerous again, arguing that they may exist in a state of tumor dormancy.|*Gene Silencing[MESH]|*Genes, myc[MESH]|Animals[MESH]|Apoptosis[MESH]|Cell Differentiation[MESH]|Gene Expression Regulation, Neoplastic[MESH]|Humans[MESH]|Liver Neoplasms/*genetics/*pathology[MESH]|Mice[MESH]|Mice, Transgenic[MESH]|Neoplastic Stem Cells/pathology[MESH] |