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lüll The circuitry of a master switch: Myod and the regulation of skeletal muscle gene transcription Tapscott SJDevelopment 2005[Jun]; 132 (12): 2685-95The expression of Myod is sufficient to convert a fibroblast to a skeletal muscle cell, and, as such, is a model system in developmental biology for studying how a single initiating event can orchestrate a highly complex and predictable response. Recent findings indicate that Myod functions in an instructive chromatin context and directly regulates genes that are expressed throughout the myogenic program, achieving promoter-specific regulation of its own binding and activity through a feed-forward mechanism. These studies are beginning to merge our understanding of how lineage-specific information is encoded in chromatin with how master regulatory factors drive programs of cell differentiation.|Animals[MESH]|Basic Helix-Loop-Helix Transcription Factors[MESH]|Chromatin/genetics/metabolism[MESH]|DNA-Binding Proteins/genetics/metabolism[MESH]|Gene Expression Regulation/*genetics[MESH]|Humans[MESH]|Muscle, Skeletal/cytology/growth & development/*metabolism[MESH]|MyoD Protein/*metabolism[MESH]|Transcription Factors/genetics/metabolism[MESH]|Transcription, Genetic/*genetics[MESH] |