Warning: Undefined variable $zfal in C:\Inetpub\vhosts\kidney.de\httpdocs\mlpefetch.php on line 525
Deprecated: str_replace(): Passing null to parameter #3 ($subject) of type array|string is deprecated in C:\Inetpub\vhosts\kidney.de\httpdocs\mlpefetch.php on line 525
Warning: Undefined variable $sterm in C:\Inetpub\vhosts\kidney.de\httpdocs\mlpefetch.php on line 530
free
Warning: Undefined variable $sterm in C:\Inetpub\vhosts\kidney.de\httpdocs\mlpefetch.php on line 531
free free
English Wikipedia
Nephropedia Template TP (
Twit Text
DeepDyve Pubget Overpricing |
lüll Nitrosative stress and pharmacological modulation of heart failure Pacher P; Schulz R; Liaudet L; Szabo CTrends Pharmacol Sci 2005[Jun]; 26 (6): 302-10Dysregulation of nitric oxide (NO) and increased oxidative and nitrosative stress are implicated in the pathogenesis of heart failure. Peroxynitrite is a reactive oxidant that is produced from the reaction of nitric oxide with superoxide anion and impairs cardiovascular function through multiple mechanisms, including activation of matrix metalloproteinases (MMPs) and nuclear enzyme poly(ADP-ribose) polymerase (PARP). Recent studies suggest that the neutralization of peroxynitrite or pharmacological inhibition of MMPs and PARP are promising new approaches in the experimental therapy of various forms of myocardial injury. In this article, the role of nitrosative stress and downstream mechanisms, including activation of MMPs and PARP, in various forms of heart failure are discussed and novel emerging therapeutic strategies offered by neutralization of peroxynitrite and inhibition of MMPs and PARP in these pathophysiological conditions are reviewed.|*Oxidative Stress[MESH]|Enzyme Activation[MESH]|Enzyme Inhibitors/therapeutic use[MESH]|Heart Failure/*drug therapy/*metabolism[MESH]|Humans[MESH]|Matrix Metalloproteinase 2/metabolism[MESH]|Matrix Metalloproteinase 9/metabolism[MESH]|Nitric Oxide Synthase/physiology[MESH]|Nitric Oxide/*physiology[MESH]|Peroxynitrous Acid/toxicity[MESH]|Poly(ADP-ribose) Polymerase Inhibitors[MESH]|Poly(ADP-ribose) Polymerases/metabolism[MESH] |