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Osteomyelitis of the foot and toe in adults is a surgical disease: conservative management worsens lower extremity salvage Henke PK; Blackburn SA; Wainess RW; Cowan J; Terando A; Proctor M; Wakefield TW; Upchurch GR Jr; Stanley JC; Greenfield LJAnn Surg 2005[Jun]; 241 (6): 885-92; discussion 892-4OBJECTIVE: To characterize the national epidemiology of adult osteomyelitis (OM) and, using a single institutions' experience, test the hypothesis that early surgical therapy as compared with antibiotics alone results in an improved chance of wound healing and limb salvage. BACKGROUND: Foot and digit OM is a very common problem for which management is variable and for which few guidelines exist. METHODS: The Nationwide Inpatient Sample (NIS) and a single institution review from 1993 to 2000 form the basis of this study, using ICD-9CM codes for lower extremity foot and digit OM. Demographics, risk factors, and treatments were analyzed against the outcomes of a healed wound, limb salvage, and death. RESULTS: The NIS included 51,875 patients (incidence = 9/10,000 patients per year) with a mean age of 60 years, and 59% were men. The median length of stay decreased from 9 to 6 days (P < 0.001), but the average admission charge of 19,000 dollars did not significantly decrease over 7 years. Of these patients, 23% underwent a digit amputation and 8.5% suffered proximal limb loss. Single-institution analysis of 237 consecutive patients with OM confirmed a similar mean age (58 years), gender (67% men), and most presented with a foot or digit ulcer (56%). Wound healing was achieved in 56% and overall limb salvage was 80%. Decreased wound healing was associated with peripheral vascular occlusive disease (odds ratio, 0.4; 95% confidence interval, 0.2-0.8, P = 0.006) and preadmission antibiotic use (odds ratio, 0.2; 95% confidence interval, 0.05-1.1, P=0.07), while surgical debridement (odds ratio, 2.2; 95% confidence interval, 1.2-4.2, P = 0.02) was associated with increased healing. Limb salvage was improved with an arterial bypass (odds ratio, 3.9; 95% confidence interval, 1.1-14, P = 0.04), while preadmission solid organ transplant (odds ratio, 0.37; 95% confidence interval, 0.14-0.96, P = 0.04), peripheral vascular occlusive disease (odds ratio, 0.25; 95% confidence interval, 0.12-0.5, P = 0.001), and preadmission antibiotic use (odds ratio, 0.34; 95% confidence interval, 0.15-0.77, P = 0.009) were associated with greater limb loss. CONCLUSION: Digit OM is an expensive and morbid disease. Aggressive surgical debridement/digit amputation and selected use of arterial bypass should improve wound healing and limb salvage, respectively. In contrast, antibiotic therapy alone is associated with decreased wound healing and limb salvage.|*Limb Salvage/statistics & numerical data[MESH]|Aged[MESH]|Anti-Bacterial Agents/therapeutic use[MESH]|Comorbidity[MESH]|Debridement[MESH]|Diabetes Mellitus/epidemiology[MESH]|Female[MESH]|Foot Diseases/diagnosis/drug therapy/epidemiology/*surgery[MESH]|Humans[MESH]|Male[MESH]|Middle Aged[MESH]|Osteomyelitis/diagnosis/drug therapy/epidemiology/*surgery[MESH]|Peripheral Vascular Diseases/epidemiology[MESH]|Toes[MESH]|Treatment Outcome[MESH]|Wound Healing[MESH] |
