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lüll No rest for REST: REST/NRSF regulation of neurogenesis Lunyak VV; Rosenfeld MGCell 2005[May]; 121 (4): 499-501Epigenetic strategies control the orderly acquisition and maintenance of neuronal traits. A complex network of transcriptional repressors and co-repressors mediates gene specificity for these strategies. In this issue of Cell, a study by Ballas and coworkers (Ballas et al., 2005) provides insight into the early lineage commitment events during neurogenesis. This study demonstrates that regulation of the REST/NRSF transcriptional repressor plays a fundamental role in the progression of pluripotent cells to lineage-restricted neural progenitors.|Animals[MESH]|Cell Differentiation/*physiology[MESH]|Cell Lineage/physiology[MESH]|Epigenesis, Genetic/physiology[MESH]|Gene Expression Regulation, Developmental/physiology[MESH]|Humans[MESH]|Nervous System/cytology/embryology/*metabolism[MESH]|Neurons/cytology/*metabolism[MESH]|Pluripotent Stem Cells/cytology/*metabolism[MESH]|Repressor Proteins/genetics/*metabolism[MESH]|Transcription Factors/genetics/*metabolism[MESH] |