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lüll Chromosome bi-orientation on the mitotic spindle Tanaka TUPhilos Trans R Soc Lond B Biol Sci 2005[Mar]; 360 (1455): 581-9For proper chromosome segregation, sister kinetochores must attach to microtubules extending from opposite spindle poles prior to anaphase onset. This state is called sister kinetochore bi-orientation or chromosome bi-orientation. The mechanism ensuring chromosome bi-orientation lies at the heart of chromosome segregation, but is still poorly understood. Recent evidence suggests that mal-oriented kinetochore-to-pole connections are corrected in a tension-dependent mechanism. The cohesin complex and the Ipl1/Aurora B protein kinase seem to be key regulators for this correction. In this article, I discuss how cells ensure sister kinetochore bi-orientation for all chromosomes, mainly focusing on our recent findings in budding yeast.|*Models, Biological[MESH]|Aurora Kinases[MESH]|Cell Cycle Proteins[MESH]|Chromosomal Proteins, Non-Histone[MESH]|Chromosome Segregation/*physiology[MESH]|Chromosomes, Fungal/*metabolism[MESH]|Cohesins[MESH]|Fungal Proteins[MESH]|Kinetochores/*metabolism[MESH]|Microtubules/metabolism[MESH]|Nuclear Proteins/metabolism[MESH]|Protein Serine-Threonine Kinases/metabolism[MESH]|Saccharomycetales[MESH]|Spindle Apparatus/metabolism/*physiology[MESH] |