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lüll Towards understanding the molecular basis of bacterial DNA segregation Leonard TA; Moller-Jensen J; Lowe JPhilos Trans R Soc Lond B Biol Sci 2005[Mar]; 360 (1455): 523-35Bacteria ensure the fidelity of genetic inheritance by the coordinated control of chromosome segregation and cell division. Here, we review the molecules and mechanisms that govern the correct subcellular positioning and rapid separation of newly replicated chromosomes and plasmids towards the cell poles and, significantly, the emergence of mitotic-like machineries capable of segregating plasmid DNA. We further describe surprising similarities between proteins involved in DNA partitioning (ParA/ParB) and control of cell division (MinD/MinE), suggesting a mechanism for intracellular positioning common to the two processes. Finally, we discuss the role that the bacterial cytoskeleton plays in DNA partitioning and the missing link between prokaryotes and eukaryotes that is bacterial mechano-chemical motor proteins.|*Bacterial Physiological Phenomena[MESH]|*Models, Biological[MESH]|Bacterial Proteins/genetics/*physiology[MESH]|Cell Division/genetics/*physiology[MESH]|Chromosome Segregation/*physiology[MESH]|Cytoskeleton/*physiology[MESH]|Molecular Motor Proteins/physiology[MESH]|Plasmids/*physiology[MESH] |