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lüll Intensity-modulated radiation therapy: emerging cancer treatment technology Hong TS; Ritter MA; Tome WA; Harari PMBr J Cancer 2005[May]; 92 (10): 1819-24The use of intensity-modulated radiation therapy (IMRT) is rapidly advancing in the field of radiation oncology. Intensity-modulated radiation therapy allows for improved dose conformality, thereby affording the potential to decrease the spectrum of normal tissue toxicities associated with IMRT. Preliminary results with IMRT are quite promising; however, the clinical data is relatively immature and overall patient numbers remain small. High-quality IMRT requires intensive physics support and detailed knowledge of three-dimensional anatomy and patterns of tumour spread. This review focuses on basic principles, and highlights the clinical implementation of IMRT in head and neck and prostate cancer.|Dose-Response Relationship, Radiation[MESH]|Head and Neck Neoplasms/*radiotherapy[MESH]|Humans[MESH]|Male[MESH]|Prostatic Neoplasms/*radiotherapy[MESH]|Quality Control[MESH]|Radiotherapy, Conformal/*methods/standards[MESH] |