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Heparin-induced thrombocytopenia: principles for early recognition and management Bartholomew JR; Begelman SM; Almahameed ACleve Clin J Med 2005[Apr]; 72 Suppl 1 (ä): S31-6Heparin-induced thrombocytopenia (HIT) is a potentially devastating complication of therapy with either unfractionated or low-molecular-weight heparin. Thrombocytopenia is no longer essential for the diagnosis of HIT, since a 50% drop in the platelet count may be a more specific indicator. Once HIT is clinically suspected, heparin should be stopped immediately and direct thrombin inhibitor therapy started; waiting for laboratory confirmation may be catastrophic.|Anticoagulants/administration & dosage/*adverse effects[MESH]|Arginine/analogs & derivatives[MESH]|Heparin, Low-Molecular-Weight/administration & dosage/adverse effects[MESH]|Heparin/administration & dosage/*adverse effects[MESH]|Hirudins/administration & dosage/*analogs & derivatives[MESH]|Humans[MESH]|Pipecolic Acids/administration & dosage/therapeutic use[MESH]|Platelet Count[MESH]|Practice Guidelines as Topic[MESH]|Recombinant Proteins/administration & dosage/therapeutic use[MESH]|Risk Assessment[MESH]|Sulfonamides[MESH]|Thrombocytopenia/*chemically induced/diagnosis/prevention & control[MESH]|Time Factors[MESH] |
